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Availability of code The actual code used to run the analyses described in this study is available at the github site at Abbreviations 5HT: 5-Hydroxytryptamine, as known as serotonin BaP: Benzo[a]pyrene BMI: Body mass index cML-MA: A constrained maximum likelihood and model averaging-based MR method CNS: Central nervous system FDR: False discovery rate GABA: -Aminobutyric acid GWAS: Genome-wide association study InSIDE: Instrument Strength Independent of Direct Effect IV: Instrument variable IVW: Inverse-variance weighted LD: Linkage disequilibrium mbQTL: Microbial quantitative trait locus MR: Mendelian randomization MR-PRESSO: MR pleiotropy residual sum and outlier MVMR: Multivariable Mendelian randomization NNK: Nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Pglyrp2: PGN-sensing molecules PGN: Peptidoglycan RCT: Randomized controlled trial SNP: Single-nucleotide polymorphism References W.H.O: Tobacco

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