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PMC 1934071

1416 This higher concentration of nicotine could potentially provide better relief from cravings, particularly in severely nicotine-dependent individuals

However, whether CSE activates an MKK3/p38-dependent PRKN Ser131 phosphorylation axis to causally suppress PRKN-mediated mitophagy, thereby driving mtROS accumulation and epithelial senescence, has not been established in COPD-relevant models

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