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The Practice Parameters Committee of the American College of Gastroenterology

In moderate doses, the short-term effects include: Faster heart rate Loss of coordination Excessive sweating Disorientation or confusion Elevated body temperature Nausea and vomiting Faster breathing Hallucinations Detachment from reality In high doses, PCP users may experience: Intense anxiety or fear Exaggerated strength Aggressive or violent behaviors Muscle spasms Seizures Coma People may experience life-threatening complications that require immediate medical treatment

And that's just cardiovascular effects -- other researchers are still exploring the relationship between marijuana smoke and long-term cancer risk

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After reviewing the companys PMTAs, the FDA determined that the applications lacked sufficient evidence to demonstrate that permitting the marketing of the products would be appropriate for the protection of the public health, which is the applicable standard legally required by the 2009 Family Smoking Prevention and Tobacco Control Act