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5.2 MRGPRX2: an emerging pruritogenic target MRGPRX2 is a member of the G protein-coupled receptor (GPCR) superfamily and functions as a critical signaling hub that links extracellular stimuli to intracellular responses (152, 153)

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Pharmacological studies have confirmed that anti-inflammatory and immunomodulatory effects were mainly found in 14- and 15-membered ring macrolides, such as EI and AZI [63], which may explain why SPI showed no obvious effects on CS-induced airway epithelial barrier dysfunction

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