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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

The Associated Press (13 de xunetu de 2006)

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It also manufactures Marlboro under a licensing agreement with Philip Morris

To test this hypothesis for MLE-12 cells, they were treated with 0% or 8% CSE for 8 generations, then transfected with SIRT1 siRNA