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Acknowledgements The authors thank Gregory Conner PhD for his insightful guidance and expertise, Professor Marianne Geiser for her valuable comments in preparing the manuscript, Nathalie Baumlin for her technical assistance with HBE cell cultures and Mir Anwar for his assistance with the fluorescence immunohistochemistry micrographs

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The results (Tables 24) identify different clubs, and corresponding estimated , where =2 is the scaled coefficient of the speed of convergence of the club, and is the estimated speed of convergence for any club 22

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