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Heres what you need to know about the marijuana legalization usage study: The JAMA study findings Research shows significant increases in substance use: Published Friday in JAMA Network Open Analysis of 55,406 adults from 2013 to 2022 panels Monthly marijuana use rose by 3.28% after legalization Tobacco e-cigarette use increased by 1.39% after legalization The dispensary effect Usage accelerated after retail operations opened: Both indicators increased faster after marijuana dispensaries opened Study found no differential change in conventional cigarette smoking Results show correlation between retail availability and usage rates Dispensary openings appear to drive additional consumption The population impact Harvard researcher calculates millions affected: Dr