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Alveolar macrophages from smoke-exposed mice challenged with nontypeable Haemophilus influenzae elicited increased levels of inflammatory mediators, such as MCP-1, MCP-3, MCP-5, IP-10, and MIP-1, whereas the expression of pro-inflammatory cytokines, namely TNF-, IL-1, IL-6, was decreased in comparison with bacteria-challenged control mice

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Together, these studies suggest a possible dose-response risk, though further research is needed to confirm this relationship

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