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For those who smoke pipes or cigars, chew tobacco, or use snuff, the resulting cancer is mainly found in areas that have been directly exposed to the tobacco, such as the mouth, throat, nose, and sinuses

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Recently, it was demonstrated that ATP-P2X7-inflammasome-caspase 1-IL-1/18 axis played a role in smoke-induced airway inflammation in healthy smokers or COPD patients as well as murine COPD models, with increased activation of P2X7 receptor/caspase 1 and elevated IL-1 and IL-18 levels (56)

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