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At 6 months, 401 (32.4%) participants in the cytisine group and 366 (29.7%) in the placebo group had achieved continuous abstinence

Endothelial activation and injury by cigarette smoke exposure

In addition, some of the flavoring chemicals have been reported to be harmful to cells in the lung including cinnamaldehyde (cinnamon flavor), diacetyl and 2,3-pentanedione or acetoin (butter flavor), maltol (malt flavor), pulegone (menthol and mint flavor) (Zaccone et al., 2015