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Table 8: Medically Important Adverse Reactions That Occurred in less than 1% of Ciprofloxacin Patients In randomized, double-blind controlled clinical trials comparing ciprofloxacin tablets [500 mg two times daily (BID)] to cefuroxime axetil (250 mg500 mg BID) and to clarithromycin (500 mg BID) in patients with respiratory tract infections, ciprofloxacin demonstrated a CNS adverse reaction profile comparable to the control drugs

For example, nicotine induces uncoupling protein1 (UCP1), a protein involved in thermogenesis in BAT, in white and brown adipose tissues [248, 249]

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Therefore, if the endogenous concentration of these irritants reaches high enough levels, coughing could be directly induced without any environmental challenge

BMS has no known cause

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