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While you cannot be strictly allergic to pure nicotine, an individual can experience extreme allergic hypersensitivity to the thousands of chemical combustion toxins, acrid gases, and formaldehyde compounds embedded inside burning tobacco smoke clouds

13 Should I stop breastfeeding if I smoke

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The proposed framework can guide further research in this area.

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It is a complex brain disease characterized by compulsive, at times uncontrollable drug craving, seeking, and use despite devastating consequences - behaviors that stem from drug-induced changes in the brain." Scientists have documented how nicotine physically alters the brain