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Neuropeptide-induced MCs degranulation leads to release of pruritogenic mediators, which further sensitize neurons and promote additional neuropeptide release ( + subsets, have been shown to tonically release glutamate, thereby restraining MCs hyperresponsiveness through regulation of Mrgprb2 expression (115)

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5 During the 10-year observational period of this study, 4307 subjects had new-onset CKD stage 1 or 2 and 19 411 subjects had new-onset CKD stage 35

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10.1164/ajrccm.162.6.2003112