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A recent study has demonstrated that ever-smokers (current and former) have an upregulated pulmonary angiotensin-converting-enzyme-2 (ACE2) gene expression, thus leading to an increased risk for viral binding and entry of both SARS-CoV and SARS-CoV-2 in their lungs [10]

Plus, women who went cold turkey were associated with a 23 percent decreased risk

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doi:10.1039/D4VA00364K

The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling