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In NP tissues from patients with intervertebral disc degeneration (IVDD), NLRP3 inflammasome activation promotes the release of inflammatory cytokines such as IL-1, which is considered to be a key mediator of IVDD [85, 86]

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Silvers, C.R., Liu, Y.R., Wu, C.H., Miyamoto, H., Messing, E.M., & Lee, Y.F