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The results obtained cannot establish causal relationships, as essentially more than half of the studies were cross-sectional

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It is strongly associated with the development and progression of hepatic steatosis, increased oxidative stress, mitochondrial dysfunction, activation of pro-inflammatory and pro-fibrotic pathways, and systemic metabolic dysregulation

Even after initial healing, smoking significantly increases the long-term risk of peri-implantitis and other oral health issues, potentially compromising implant longevity