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While smokeless nicotine products are generally considered safer than burnt tobacco, they still cause mouth irritation, lesions and gum damage, are linked to oral cancer and cardiovascular and metabolic risks and are associated with nicotine dependence, especially with longterm or highdose use

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neck pain), which were usually reported as either mild or moderate and resolved shortly after treatment

Over the ensuing three centuries, tobacco would be a mainstay of the British economy, and Great Britain would be the leading tobacco merchant to the world

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