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Most Single Products Have Either a Negligible or Unknowable Population Impact The FDA has interpreted the 2009 law in a maximalist and risk-averse manner, considering the PMTA process specific to each single product

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17 Moreover, there are few contraindications for the use of NRTs, with some of the more common ones being an allergy to the nicotine patch adhesive, temporomandibular joint disease for the nicotine gum, and gastric or duodenal ulcer for the nicotine nasal spray