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Bangalore S, Messerli FH, Wun C, Zuckerman AL, De Micco D, Kostis JB, La Rosa JC

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Genes were identified as differentially expressed if they met both an FDR-adjusted p -value 1

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The deregulation of NO synthesis (both up- and down-regulation, depending on the arsenic concentration) is interesting because this is a signal messenger that promotes vascular relaxation, but during pathological processes, it generates nitrogen reactive species and oxidative stress, damaging the endothelium (138, 139)