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Our results suggested that: (1) model organism genes accounted for ~536% of the observed SNP-heritability in human tobacco consumption (enrichment: 1.6031.45), (2) model organism genes, but not negative control genes, were enriched for the gene-based associations (MAGMA, H-MAGMA, SMultiXcan) for human cigarettes per day, and (3) polygenic scores based on our model organism geneset predicted cigarettes per day in an independent sample

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DATA AVAILABILITY Data sharing is not applicable to this article as no new data were created

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Bevo was a non-alcoholic malt beverage, a steppingstone to beer in the same way that cubebs led the way to tailor-made (machine-made) cigarettes