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ITC Project investigators compared the smoking rates in Canada before and after the implementation of pictorial HWLs, taking into account the price of cigarettes, and found that pictorial HWLs were effective in decreasing overall smoking rates by 2.94.7% [19]

It is known that this chemical induces tolerance and overtime show reduced effectiveness, making dyskinesias reappear 56,57

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Acknowledgments The authors gratefully acknowledge Bloomberg philanthropies for their generous support of this activity