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According to a 2015 interview in Billboard , Van Halen had undergone partial removal of his tongue (partial glossectomy) for tongue cancer, at that time already extending into his throat and esophagus

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Conversely, smoking seems to increase rates of toxic metals like manganese and chromium in the body as well as the build-up of chromium in hair

The activation of AR may vary depending on whether naturally produced or commercially available hormones are being used, as well as whether metabolic products of androgens are being generated [e.g., testosterone is metabolized by 5-reductase to the more potent AR ligand, DHT