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"After slamming a high number of keystone lights, Doug got poopchute drunk and a 220lb party bison found him half passed out on a couch, jumped on his dick and he stuck it in cold smokey." When you beer is so cold the frost cloud rolls down the side of the can/glass

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And I go, This could be it

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Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells