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Since its initial approval, Enbrel's label has been expanded to include four additional "TNF-related" maladies, including psoriatic arthritis, ankylosing spondylitis and plaque psoriasis

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However, the amount of exercise required to achieve practically meaningful changes in fat mass (100 min/day) is not feasible for most of the general public and thus has limited practical relevance

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The medication is administered as a once-weekly subcutaneous injection and functions through several mechanisms