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Theoretically, this protects the organism from cells whose DNA has been so significantly damaged that repair of the genome would lead to unacceptably high mutation rates

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If you consume nicotine in any form or know someone who does, you will shortly start noticing discolouration and yellowing of the teeth

As pleural mesothelioma progresses, it can also cause other symptoms and complications such as difficulty swallowing, pain due to pressure on the nerves in the chest, pleural thickening, pleural effusion (fluid buildup in the chest cavity), which can compress the lungs and cause difficulties with breathing

Twist that thing and see what happens