Epidemiology Bimodal age distribution: 1530 yrs and 5070 yrs Slight male predominance Higher prevalence in urban populations Etiology & Pathogenesis Multifactorial: genetic predisposition + immune dysregulation + environmental triggers Inflammation limited to mucosa and submucosa Begins in the rectum extends proximally (continuous lesions) Clinical Features Intestinal: Bloody diarrhea Mucus in stool Tenesmus Urgency Abdominal pain (LLQ) Systemic: Fatigue Weight loss Fever (severe disease) Extra-intestinal Manifestations Musculoskeletal: Peripheral arthritis, sacroiliitis Skin: Erythema nodosum, pyoderma gangrenosum Eyes: Uveitis, episcleritis Hepatobiliary: Primary sclerosing cholangitis (PSC) Extent (Montreal classification simplified) Proctitis rectum only Left-sided colitis up to splenic flexure Pancolitis entire colon Diagnosis Colonoscopy with biopsy gold standard Continuous erythema, friability, ulceration Histology: Crypt abscesses, mucosal inflammation Labs: ESR/CRP, anemia Exclude infection (stool cultures, C
This week aims to provide education to help prevent youth and young adults from starting to use tobacco products, while also helping existing tobacco consumers to quit or limit their intake, thus helping protect everyone from the dangers of second- and third-hand smoke
In the years immediately following 2001, many state governments had trouble balancing their budgets due to the Internet stock decline and the economic slowdown following the terrorist attacks of Sept
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We never did get our "find a reason to change" as he silently slipped away from me, not telling me that he was losing interest
As to why it caught on: I guess it sounded like swearing, said Rickles, who never used profanity in his act
