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Historically, the Hanafi school of thought classified smoking as Makrooh rather than Haram due to the lack of explicit prohibition and less conclusive evidence of harm at the time

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[9] Leukoplakia is, therefore, the most common premalignant lesion that occurs in the mouth

The response of cells to hypoxia is regulated by the hypoxia-inducing factor-1 (HIF-1), which is a major transcription regulatory factor and also plays a central role in the activation of mitophagy (Li et al., 2019

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